Estrogenic Effects of Tapak Dara (Catharantus roseus) Leaf Methanol Extract on The Estrus Cycle of Adult Female Mice (Mus musculus) Balb/C Strain

Tapak dara plant is a that contains several active compounds, such as phenolic acids, flavonoids and alkaloids. The tapak can act sedative, urinary laxative, stop bleeding, neutralize toxins. In addition, leaf extract ingredients antifertilization. This study aimed to determine the effect of methanol on estrus cycle adult female mice (Mus musculus) Balb/C strain. research an experimental by testing cause effect. hypothesis test used in this was one-way ANOVA BNT test. significance value giving showed significant so it be said administration caused longer. estrogenic activity shows 0.047, estrogen also affects length cycle. results using were significant, concluded leaves